Research Interests

Mr Yiangou has a sustained interest in research in both his specialist fields - breast and endocrine. This includes research into the following areas

sentinel lymph node biopsy in breast cancer
pre-operative assessment of sentinel lymph node which will help determine immediately which patients will benefit from axillary dissection
genetic alterations in breast cells which lead to the development of breast cancer and determine prognosis and response to treatment
predicting lymph node involvement in breast cancer
evaluation of new drug therapies for breast cancer
improving the accuracy of pre-operative diagnosis of thyroid nodules

You may be interested to read more about his research - or you may wish to skip the remainder of this section!

The first item below is a link to one of the most important papers which led to the introduction of Sentinel Lymph Node Biopsy (SLNB) not just in the UK, but in Europe. Mr Yiangou was one of 20 authors of this paper and he contributed a significant number of patients to this trial. The paper below was published in 2006 in the Journal of the National Cancer Institute [JNCI 2006 98(9):599-609 ]

Randomized Multicenter Trial of Sentinel Node Biopsy Versus Standard Axillary Treatment in Operable Breast Cancer: The ALMANAC Trial

Below you will find a list of his papers with references which will enable you to find these documents online.

Breast cancer follow up: a randomised controlled trial comparing point of need access versus routine 6-monthly clinical review

Sheppard C, Higgins B, Wise M, Yiangou C, Dubois D, Kilburn S

Eur J Oncol Nurs. 2009 Feb;13(1):2-8. Epub 2008 Dec 31

Thyroid FNAC cytology: can we do it better?

Poller DN, Stelow EB, Yiangou C

Cytopathology. 2008 Feb;19(1):4-10. Epub 2007 Oct 3. Review

PMID: 17916090 [PubMed - indexed for MEDLINE]

A double-blind randomised trial to evaluate the effect of anastrozole for the treatment of non-toxic multinodular goitre

Knight JS, Satchidanand RY, Yiangou C, Jackson A, Cummings MH

Int J Clin Pract. 2006 Aug;60(8):911-3. Epub 2006 Jun 2

PMID: 16749914 [PubMed - indexed for MEDLINE]

Randomized multicenter trial of sentinel node biopsy versus standard axillary treatment in operable breast cancer: the ALMANAC Trial

Mansel RE, Fallowfield L, Kissin M, Goyal A, Newcombe RG, Dixon JM, Yiangou C, Horgan K, Bundred N, Monypenny I, England D, Sibbering M, Abdullah TI, Barr L, Chetty U, Sinnett DH, Fleissig A, Clarke D, Ell PJ

J Natl Cancer Inst. 2006 May 3;98(9):599-609. Erratum in: J Natl Cancer Inst. 2006 Jun 21;98(12):876

PMID: 16670385 [PubMed - indexed for MEDLINE]

Radiological review of specimen radiographs after breast localisation biopsy is not always necessary. Coombs NJ, Vassallo PP, Parker AJ, Yiangou C.

Eur J Surg Oncol. 2006 Jun;32(5):516-9. Epub 2006 Apr 27.

PMID: 16644176 [PubMed - indexed for MEDLINE]

Cancer cell adaptation to chemotherapy

Di Nicolantonio F, Mercer SJ, Knight LA, Gabriel FG, Whitehouse PA, Sharma S, Fernando A, Glaysher S, Di Palma S, Johnson P, Somers SS, Toh S, Higgins B, Lamont A, Gulliford T, Hurren J, Yiangou C, Cree IA.

BMC Cancer. 2005 Jul 18;5:78

PMID: 16026610 [PubMed - indexed for MEDLINE]

Galectin-3 is not useful in thyroid FNA

Mills LJ, Poller DN, Yiangou C

Cytopathology. 2005 Jun;16(3):132-8

PMID: 15924608 [PubMed - indexed for MEDLINE]

Sentinel lymph node biopsy in male breast cancer patients.

Goyal A, Horgan K, Kissin M, Yiangou C, Sibbering M, Lansdown M, Newcombe RG, Mansel RE, Chetty U, Ell P, Fallowfield L, Kissin M; ALMANAC Trialists Group.

Eur J Surg Oncol. 2004 Jun;30(5):480-3.

PMID: 15135473 [PubMed - indexed for MEDLINE]

The use of sentinel node biopsy in the treatment of cancer of an accessory breast.
Thorne AL, Jackson A, Yiangou C

Breast. 2003 Apr;12(2):153-5.

PMID: 14659346 [PubMed - indexed for MEDLINE]

Letter 2: Bone marrow micrometastasis in breast cancer (Br J Surg 2003; 90: 290-301).

Ferguson DJ, Yiangou C.

Br J Surg. 2003 Jun;90(6):761-2. No abstract available

PMID: 12808638 [PubMed - indexed for MEDLINE]

Relationship between serum prolactin levels and histology of benign and malignant breast lesions: a detailed study of 153 consecutive cases.

Nicol M, Willis C, Yiangou C, Sinnett D, Shousha S

Breast J. 2002 Sep-Oct;8(5):281-5.

PMID: 12199755 [PubMed - indexed for MEDLINE]

Thyroid FNA and benign thyroid disease

Poller D, Yiangou C, Cummings M, Boote D.

Lancet. 2000 Aug 19;356(9230):679. No abstract available.

PMID: 10968459 [PubMed - indexed for MEDLINE]

The missing mammographic abnormality

Zammit C, Yiangou C, Sinnett HD

Br J Surg. 2000 Mar;87(3):374; author reply 374-5. No abstract available

PMID: 10755835 [PubMed - indexed for MEDLINE]

Correspondence: the missing mammographic abnormality
Zammit C, Yiangou C, Sinnett HD.

Br J Surg. 2000 Mar;87(3):374-80. No abstract available

PMID: 10718976 [PubMed - as supplied by publisher]

Primary tumour characteristics and axillary lymph node status in breast cancer.

Yiangou C, Shousha S, Sinnett HD.

Br J Cancer. 1999 Aug;80(12):1974-8.

PMID: 10471048 [PubMed - indexed for MEDLINE]

Sigmoido-appendiceal fistula due to diverticulitis

Yiangou C, Holme TC

J R Soc Med. 1998 Oct;91(10):544. No abstract available

PMID: 10070382 [PubMed - indexed for MEDLINE]

A paracrine role for myoepithelial cell-derived FGF2 in the normal human breast.

Gomm JJ, Browne PJ, Coope RC, Bansal GS, Yiangou C, Johnston CL, Mason R, Coombes RC.

Exp Cell Res. 1997 Jul 10;234(1):165-73

PMID: 9223382 [PubMed - indexed for MEDLINE]

Down-regulation of a novel form of fibroblast growth factor receptor 1 in human breast cancer

Yiangou C, Cox H, Bansal GS, Coope R, Gomm JJ, Barnard R, Walters J, Groome N, Shousha S, Coombes RC, Johnston CL.

Br J Cancer. 1997;76(11):1419-27

PMID: 9400937 [PubMed - indexed for MEDLINE]

The location of acidic fibroblast growth factor in the breast is dependent on the activity of proteases present in breast cancer tissue.
Coope RC, Browne PJ, Yiangou C, Bansal GS, Walters J, Groome N, Shousha S, Johnston CL, Coombes RC, Gomm JJ.

PMID: 9184178 [PubMed - indexed for MEDLINE]

Expression of keratinocyte growth factor and its receptor in human breast cancer

Bansal GS, Cox HC, Marsh S, Gomm JJ, Yiangou C, Luqmani Y, Coombes RC, Johnston CL.

Br J Cancer. 1997;75(11):1567-74.

PMID: 9184170 [PubMed - indexed for MEDLINE]

Fibroblast growth factor 2 in breast cancer: occurrence and prognostic significance.

Yiangou C, Gomm JJ, Coope RC, Law M, Luqmani YA, Shousha S, Coombes RC, Johnston CL.

Br J Cancer. 1997;75(1):28-33

PMID: 9000594 [PubMed - indexed for MEDLINE

Fibromatosis of the breast or carcinoma?

Yiangou C, Fadl H, Sinnett HD, Shousha S.

J R Soc Med. 1996 Nov;89(11):638-40. No abstract available

PMID: 9135594 [PubMed - indexed for MEDLINE]

Diagnostic role of cytology in screen-detected breast cancer.

Yiangou C, Davis J, Livni N, Barrett NK, Sinnett HD

Br J Surg. 1996 Jun;83(6):816-9

PMID: 8696750 [PubMed - indexed for MEDLINE]

Expression of fibroblast growth factor 1 is lower in breast cancer than in the normal human breast.

Bansal GS, Yiangou C, Coope RC, Gomm JJ, Luqmani YA, Coombes RC, Johnston CL

Br J Cancer. 1995 Dec;72(6):1420-6.

PMID: 8519654 [PubMed - indexed for MEDLINE]

Expression of 2 variant forms of fibroblast growth factor receptor 1 in human breast.

Luqmani YA, Mortimer C, Yiangou C, Johnston CL, Bansal GS, Sinnett D, Law M, Coombes RC.

Int J Cancer. 1995 Aug 22;64(4):274-9.

PMID: 7657392 [PubMed - indexed for MEDLINE]

Gall-bladder agenesis and associated anomalies.

Yiangou C, Shorey B, Spigelman AD.

HPB Surg. 1995;8(4):253-5.

PMID: 18612357 [PubMed - in process]

Inner city deprivation and medical education: a survey of medical students by medical students.

Yiangou C, Wood M, Wright P, Choi S, Lam TH, Morris O, Mortimore I, Poole S.

Med Educ. 1988 Jan;22(1):2-7.

PMID: 3357443 [PubMed - indexed for MEDLINE]